Routine preoperative blood grouping revealed that the patient’s blood group had changed from O, RhD-negative, to O, RhD-positive (the donor’s blood group), and a weakly positive direct antiglobulin test indicated coating of red blood cells with IgG antibodies. Nine months after transplantation, a small-bowel obstruction developed, requiring surgical division of adhesions and resection of an ileal band. The HLA status of the donor was A34,68 B50,76 DR4,13, and the recipient’s HLA status was A2,24 B37,62 DR7,9. The whole liver was transplanted (cold ischemic time, 9 hours 46 minutes), and the biliary anastomosis was a choledochocholedochostomy.
Given the patient’s fulminant hepatic failure requiring mechanical ventilation, urgent liver transplantation was performed with the use of a whole-organ transplant from an O, RhD-positive 12-year-old male donor who was positive for cytomegalovirus (CMV) (the recipient was also CMV-positive) and who died of hypoxic brain injury. A liver biopsy was not performed because of severe underlying coagulopathy. Extensive testing ruled out known viral, metabolic, drug-related, and autoimmune causes, and a diagnosis of “non–A-to-G viral hepatitis” was made. She was referred to our institution, and at the time of admission she had markedly elevated aminotransferase levels and evidence of marked synthetic dysfunction. Transplant girl’s blood change a ‘miracle’īut as I have stated before, reading a mainstream newspaper article is one thing (the interpretation of sometimes not sufficiently educated journalists can potentially bring the wrong conclusions) … finding the actual study is another thing:Īcute fulminant hepatitis after a nonspecific viral illness developed in a previously well 9-year-old girl. Then we tested her parents and they were both O-negative, so it was confirmed that Demi absolutely had to have been O-negative.” “I was convinced we had made a mistake, so we tested it again and it came up the same. The head of hematology, Julie Curtin, said she was stunned when she realised Demi-Lee was now O-positive, rather than O-negative. Nine months later, when her condition worsened and she was readmitted, doctors were shocked to find that her blood type had changed. She had the liver transplant done and then: The phenomenon, which has been documented in the New England Journal of Medicine, has amazed doctors, who say they have no idea how it occurred. The 15-year-old liver transplant patient is the first person in the world to take on the immune system and blood type of her donor, negating the need to take anti-rejection drugs for the rest of her life. There is however one story out there which documents Demi-Lee Brennan and the 1 in 6 Billion possibility of a transplant changing your blood type. And one test can show one blood type, another test the other. Then of course there are cases of chimerism where you have different blood types in your veins. And until recently I have never received additional information to any of the claims I have heard. This is one claim that has been made a lot. Scroll down to see more than one case and an rh negative changing into an rh positive and vice versa.
0 kommentar(er)
